Comparative Effectiveness of Ceftriaxone plus Metronidazole versus Anti-Pseudomonal Antibiotics for Perforated Appendicitis in Children
نویسندگان
چکیده
منابع مشابه
Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial.
INTRODUCTION Appendicitis is the most common emergency condition in children. Historically, a 3-drug regimen consisting of ampicillin, gentamicin, and clindamycin (AGC) has been used postoperatively for perforated appendicitis. A retrospective review at our institution has found single day dosing of ceftriaxone and metronidazole (CM) to be a more simple and cost-effective antibiotic strategy. T...
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BACKGROUND For more than a century, appendicectomy has been the treatment of choice for appendicitis. Recent trials have challenged this view. This study assessed the benefits and harms of antibiotic therapy compared with appendicectomy in patients with non-perforated appendicitis. METHODS A comprehensive search was conducted for randomized trials comparing antibiotic therapy with appendicect...
متن کاملComparative Study of Acute and Perforated Appendicitis
To date, surgery remains the cornerstone in the treatment of appendicitis. However, recent research has revealed that antibiotic treatment might be an appropriate alternative in selected cases [1,2]. Conservative management with antibiotics causes suppression of bacterial infection by regression of lymphoid hyperplasia. Thereby it might prevent ischemia and bacterial invasion in the early stage...
متن کاملRole of postoperative antibiotics after appendectomy in non-perforated appendicitis.
OBJECTIVE To determine the role of postoperative antibiotics in reducing the surgical site infections (SSIs) after open appendectomy in patients with non-perforated appendicitis (NPA). STUDY DESIGN Randomized controlled trial. PLACE AND DURATION OF STUDY The Department of Surgery, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia, from January 2010 to July 2011. METHODOLOGY Three hu...
متن کاملThe efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis
The aim of this study was to evaluate the efficacy of combined therapy with metronidazole and broad-spectrum antibiotics for patients with perforated appendicitis who underwent surgical intervention.Broad-spectrum antibiotic therapy is warranted in the treatment of perforated appendicitis. Metronidazole has been used as anaerobic antimicrobial therapy. However, few studies about the use of metr...
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ژورنال
عنوان ژورنال: Surgical Infections
سال: 2019
ISSN: 1096-2964,1557-8674
DOI: 10.1089/sur.2018.234